3D cardiac Chemical Shift Imaging of [1-13C] hyperpolarized acetate and pyruvate in pigs
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چکیده
منابع مشابه
3D cardiac Chemical Shift Imaging of [1-13C] hyperpolarized acetate and pyruvate in pigs
Background 13C Dynamic Nuclear Polarization (DNP) with rapid dissolution together with Magnetic Resonance Chemical Shift Imaging (CSI) have been used for non-invasive real-time metabolic assessment in cardiac experimental models on a clinical 3T scanner. Here, we report an in vivo comparison of hyperpolarized [1-13C] pyruvate and [1-13C] acetate perfusion and metabolism: a method based on a 3D ...
متن کاملDNP Methods for Cardiac Metabolic Imaging with Hyperpolarized [1-13C]pyruvate Large Dose Injection in Pigs
In this study we set up and optimized a dynamic nuclear polarization (DNP) procedure for the hyperpolarization of a large dose suitable for cardiac metabolic imaging in vivo in swine models. The dose range proposed in this study allowed chemical shift imaging of cardiac metabolism with hyperpolarized [1-C]pyruvate in pigs. We investigated the typical pattern of distribution of [1-C]pyruvate and...
متن کاملSegmental analysis of cardiac metabolism by hyperpolarized [1-13C] pyruvate: an in-vivo 3D MRI study in pigs
Methods Seven male pigs (38±2 kg) were imaged on a 3T MRI scanner (GE Excite Hdx) with a 13C birdcage coil. 13C-pyruvate (20mL of 230mM) was hyperpolarized using a Dynamic Nuclear Polarization technique (Hypersense) and injected in pigs at rest and during occlusion of the left anterior descending coronary artery. Anatomical reference images were acquired by a standard SSFP sequence. Metabolic i...
متن کاملMultiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging.
Hyperpolarized 13C offers high signal-to-noise ratios for imaging metabolic activity in vivo, but care must be taken when designing pulse sequences because the magnetization cannot be recovered once it has decayed. It has a short lifetime, on the order of minutes, and gets used up by each RF excitation. In this paper, we present a new dynamic chemical-shift imaging method that uses specialized ...
متن کاملDetection of 3D Cardiac metabolism after injection of hyperpolarized [1-13C]pyruvate
Methods Three healthy male mini-pigs (38±2 kg) were maintained under deep sedation; a dose of 20 mL of 230 mM [1-13C]pyruvate was administered over about 10 s by manual injection. Animal experiments were performed on a 3T GE Signa HDx scanner with a 13C quadrature birdcage coil. [1-13C]pyruvate was polarized using a HyperSense DNP polariser with subsequent dissolution. The final injection solut...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Magnetic Resonance
سال: 2013
ISSN: 1532-429X
DOI: 10.1186/1532-429x-15-s1-p10